PluginBench
MCP Server
Active
Apache-2.0

io.github.cyanheads/chembl-mcp-server MCP Server

io.github.cyanheads/chembl-mcp-server

What is the io.github.cyanheads/chembl-mcp-server MCP server?

Link compounds to protein targets, rank bioactivity, and look up drug mechanisms and indications.

How to install io.github.cyanheads/chembl-mcp-server

Copy-paste configuration for popular MCP clients.

transport: stdio
Config generated by PluginBench — verify against the source before use.
Environment / auth
  • CANVAS_PROVIDER_TYPE

    Set to 'duckdb' to enable the bioactivity DataCanvas spill and the chembl_dataframe_* SQL tools. When 'none', large bioactivity sets inline a preview but never spill.

  • CHEMBL_API_BASE_URL

    Base URL for the ChEMBL REST data API. Override for a private mirror or pinned host.

  • CHEMBL_REQUEST_TIMEOUT_MS

    Per-request timeout in milliseconds for upstream ChEMBL fetches.

  • CHEMBL_MAX_PAGE_SIZE

    ChEMBL per-page cap when streaming activity pages for the bioactivity spill (max 1000).

  • CHEMBL_DEFAULT_LIMIT

    Default result limit applied when callers omit it.

  • CHEMBL_DATAFRAME_DROP_ENABLED

    Set to 'true' to register the opt-in chembl_dataframe_drop tool (absent from tools/list when off).

  • MCP_LOG_LEVEL

    Sets the minimum log level for output (e.g., 'debug', 'info', 'warn').

  • MCP_HTTP_HOST

    The hostname for the HTTP server.

  • MCP_HTTP_PORT

    The port to run the HTTP server on.

  • MCP_HTTP_ENDPOINT_PATH

    The endpoint path for the MCP server.

  • MCP_AUTH_MODE

    Authentication mode to use: 'none', 'jwt', or 'oauth'.

Claude Desktop
~/Library/Application Support/Claude/claude_desktop_config.json
{
  "mcpServers": {
    "chembl-mcp-server": {
      "command": "bun",
      "args": [
        "-y",
        "@cyanheads/chembl-mcp-server",
        "run",
        "start:stdio"
      ],
      "env": {
        "CANVAS_PROVIDER_TYPE": "<YOUR_CANVAS_PROVIDER_TYPE>",
        "CHEMBL_API_BASE_URL": "<YOUR_CHEMBL_API_BASE_URL>",
        "CHEMBL_REQUEST_TIMEOUT_MS": "<YOUR_CHEMBL_REQUEST_TIMEOUT_MS>",
        "CHEMBL_MAX_PAGE_SIZE": "<YOUR_CHEMBL_MAX_PAGE_SIZE>",
        "CHEMBL_DEFAULT_LIMIT": "<YOUR_CHEMBL_DEFAULT_LIMIT>",
        "CHEMBL_DATAFRAME_DROP_ENABLED": "<YOUR_CHEMBL_DATAFRAME_DROP_ENABLED>",
        "MCP_LOG_LEVEL": "<YOUR_MCP_LOG_LEVEL>",
        "MCP_HTTP_HOST": "<YOUR_MCP_HTTP_HOST>",
        "MCP_HTTP_PORT": "<YOUR_MCP_HTTP_PORT>",
        "MCP_HTTP_ENDPOINT_PATH": "<YOUR_MCP_HTTP_ENDPOINT_PATH>",
        "MCP_AUTH_MODE": "<YOUR_MCP_AUTH_MODE>"
      }
    }
  }
}
Cursor
~/.cursor/mcp.json
{
  "mcpServers": {
    "chembl-mcp-server": {
      "command": "bun",
      "args": [
        "-y",
        "@cyanheads/chembl-mcp-server",
        "run",
        "start:stdio"
      ],
      "env": {
        "CANVAS_PROVIDER_TYPE": "<YOUR_CANVAS_PROVIDER_TYPE>",
        "CHEMBL_API_BASE_URL": "<YOUR_CHEMBL_API_BASE_URL>",
        "CHEMBL_REQUEST_TIMEOUT_MS": "<YOUR_CHEMBL_REQUEST_TIMEOUT_MS>",
        "CHEMBL_MAX_PAGE_SIZE": "<YOUR_CHEMBL_MAX_PAGE_SIZE>",
        "CHEMBL_DEFAULT_LIMIT": "<YOUR_CHEMBL_DEFAULT_LIMIT>",
        "CHEMBL_DATAFRAME_DROP_ENABLED": "<YOUR_CHEMBL_DATAFRAME_DROP_ENABLED>",
        "MCP_LOG_LEVEL": "<YOUR_MCP_LOG_LEVEL>",
        "MCP_HTTP_HOST": "<YOUR_MCP_HTTP_HOST>",
        "MCP_HTTP_PORT": "<YOUR_MCP_HTTP_PORT>",
        "MCP_HTTP_ENDPOINT_PATH": "<YOUR_MCP_HTTP_ENDPOINT_PATH>",
        "MCP_AUTH_MODE": "<YOUR_MCP_AUTH_MODE>"
      }
    }
  }
}
Windsurf
~/.codeium/windsurf/mcp_config.json
{
  "mcpServers": {
    "chembl-mcp-server": {
      "command": "bun",
      "args": [
        "-y",
        "@cyanheads/chembl-mcp-server",
        "run",
        "start:stdio"
      ],
      "env": {
        "CANVAS_PROVIDER_TYPE": "<YOUR_CANVAS_PROVIDER_TYPE>",
        "CHEMBL_API_BASE_URL": "<YOUR_CHEMBL_API_BASE_URL>",
        "CHEMBL_REQUEST_TIMEOUT_MS": "<YOUR_CHEMBL_REQUEST_TIMEOUT_MS>",
        "CHEMBL_MAX_PAGE_SIZE": "<YOUR_CHEMBL_MAX_PAGE_SIZE>",
        "CHEMBL_DEFAULT_LIMIT": "<YOUR_CHEMBL_DEFAULT_LIMIT>",
        "CHEMBL_DATAFRAME_DROP_ENABLED": "<YOUR_CHEMBL_DATAFRAME_DROP_ENABLED>",
        "MCP_LOG_LEVEL": "<YOUR_MCP_LOG_LEVEL>",
        "MCP_HTTP_HOST": "<YOUR_MCP_HTTP_HOST>",
        "MCP_HTTP_PORT": "<YOUR_MCP_HTTP_PORT>",
        "MCP_HTTP_ENDPOINT_PATH": "<YOUR_MCP_HTTP_ENDPOINT_PATH>",
        "MCP_AUTH_MODE": "<YOUR_MCP_AUTH_MODE>"
      }
    }
  }
}
VS Code
.vscode/mcp.json
{
  "servers": {
    "chembl-mcp-server": {
      "type": "stdio",
      "command": "bun",
      "args": [
        "-y",
        "@cyanheads/chembl-mcp-server",
        "run",
        "start:stdio"
      ],
      "env": {
        "CANVAS_PROVIDER_TYPE": "<YOUR_CANVAS_PROVIDER_TYPE>",
        "CHEMBL_API_BASE_URL": "<YOUR_CHEMBL_API_BASE_URL>",
        "CHEMBL_REQUEST_TIMEOUT_MS": "<YOUR_CHEMBL_REQUEST_TIMEOUT_MS>",
        "CHEMBL_MAX_PAGE_SIZE": "<YOUR_CHEMBL_MAX_PAGE_SIZE>",
        "CHEMBL_DEFAULT_LIMIT": "<YOUR_CHEMBL_DEFAULT_LIMIT>",
        "CHEMBL_DATAFRAME_DROP_ENABLED": "<YOUR_CHEMBL_DATAFRAME_DROP_ENABLED>",
        "MCP_LOG_LEVEL": "<YOUR_MCP_LOG_LEVEL>",
        "MCP_HTTP_HOST": "<YOUR_MCP_HTTP_HOST>",
        "MCP_HTTP_PORT": "<YOUR_MCP_HTTP_PORT>",
        "MCP_HTTP_ENDPOINT_PATH": "<YOUR_MCP_HTTP_ENDPOINT_PATH>",
        "MCP_AUTH_MODE": "<YOUR_MCP_AUTH_MODE>"
      }
    }
  }
}
Claude Code
claude mcp add chembl-mcp-server --env CANVAS_PROVIDER_TYPE=<YOUR_CANVAS_PROVIDER_TYPE> --env CHEMBL_API_BASE_URL=<YOUR_CHEMBL_API_BASE_URL> --env CHEMBL_REQUEST_TIMEOUT_MS=<YOUR_CHEMBL_REQUEST_TIMEOUT_MS> --env CHEMBL_MAX_PAGE_SIZE=<YOUR_CHEMBL_MAX_PAGE_SIZE> --env CHEMBL_DEFAULT_LIMIT=<YOUR_CHEMBL_DEFAULT_LIMIT> --env CHEMBL_DATAFRAME_DROP_ENABLED=<YOUR_CHEMBL_DATAFRAME_DROP_ENABLED> --env MCP_LOG_LEVEL=<YOUR_MCP_LOG_LEVEL> --env MCP_HTTP_HOST=<YOUR_MCP_HTTP_HOST> --env MCP_HTTP_PORT=<YOUR_MCP_HTTP_PORT> --env MCP_HTTP_ENDPOINT_PATH=<YOUR_MCP_HTTP_ENDPOINT_PATH> --env MCP_AUTH_MODE=<YOUR_MCP_AUTH_MODE> -- bun -y @cyanheads/chembl-mcp-server run start:stdio

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