io.github.cyanheads/chembl-mcp-server MCP Server

io.github.cyanheads/chembl-mcp-server

Repository Registry

What is the io.github.cyanheads/chembl-mcp-server MCP server?

Link compounds to protein targets, rank bioactivity, and look up drug mechanisms and indications.

How to install io.github.cyanheads/chembl-mcp-server

Copy-paste configuration for popular MCP clients.

transport: stdio

Config generated by PluginBench — verify against the source before use.

Environment / auth

CANVAS_PROVIDER_TYPE
Set to 'duckdb' to enable the bioactivity DataCanvas spill and the chembl_dataframe_* SQL tools. When 'none', large bioactivity sets inline a preview but never spill.
CHEMBL_API_BASE_URL
Base URL for the ChEMBL REST data API. Override for a private mirror or pinned host.
CHEMBL_REQUEST_TIMEOUT_MS
Per-request timeout in milliseconds for upstream ChEMBL fetches.
CHEMBL_MAX_PAGE_SIZE
ChEMBL per-page cap when streaming activity pages for the bioactivity spill (max 1000).
CHEMBL_DEFAULT_LIMIT
Default result limit applied when callers omit it.
CHEMBL_MAX_SPILL_ROWS
Ceiling on rows chembl_get_bioactivities stages to a DataCanvas table, and so on the upstream page drain behind it. Over the cap the response reports truncated: true.
CHEMBL_DATAFRAME_DROP_ENABLED
Set to 'true' to register the opt-in chembl_dataframe_drop tool (absent from tools/list when off).
MCP_LOG_LEVEL
Sets the minimum log level for output (e.g., 'debug', 'info', 'warn').
MCP_HTTP_HOST
The hostname for the HTTP server.
MCP_HTTP_PORT
The port to run the HTTP server on.
MCP_HTTP_ENDPOINT_PATH
The endpoint path for the MCP server.
MCP_AUTH_MODE
Authentication mode to use: 'none', 'jwt', or 'oauth'.

~/Library/Application Support/Claude/claude_desktop_config.json

{
  "mcpServers": {
    "chembl-mcp-server": {
      "command": "bun",
      "args": [
        "-y",
        "@cyanheads/chembl-mcp-server",
        "run",
        "start:stdio"
      ],
      "env": {
        "CANVAS_PROVIDER_TYPE": "<YOUR_CANVAS_PROVIDER_TYPE>",
        "CHEMBL_API_BASE_URL": "<YOUR_CHEMBL_API_BASE_URL>",
        "CHEMBL_REQUEST_TIMEOUT_MS": "<YOUR_CHEMBL_REQUEST_TIMEOUT_MS>",
        "CHEMBL_MAX_PAGE_SIZE": "<YOUR_CHEMBL_MAX_PAGE_SIZE>",
        "CHEMBL_DEFAULT_LIMIT": "<YOUR_CHEMBL_DEFAULT_LIMIT>",
        "CHEMBL_MAX_SPILL_ROWS": "<YOUR_CHEMBL_MAX_SPILL_ROWS>",
        "CHEMBL_DATAFRAME_DROP_ENABLED": "<YOUR_CHEMBL_DATAFRAME_DROP_ENABLED>",
        "MCP_LOG_LEVEL": "<YOUR_MCP_LOG_LEVEL>",
        "MCP_HTTP_HOST": "<YOUR_MCP_HTTP_HOST>",
        "MCP_HTTP_PORT": "<YOUR_MCP_HTTP_PORT>",
        "MCP_HTTP_ENDPOINT_PATH": "<YOUR_MCP_HTTP_ENDPOINT_PATH>",
        "MCP_AUTH_MODE": "<YOUR_MCP_AUTH_MODE>"
      }
    }
  }
}

Related MCP servers

io.github.cyanheads/cisa-cybersecurity-mcp-server

CISA KEV with BOD 26-04 deadlines, SSVC prioritization, and the ICS advisory corpus (CSAF). Keyless.

View repository →

io.github.cyanheads/clinicaltrialsgov-mcp-server

Active

Search ClinicalTrials.gov, retrieve study details and results, and match patients to eligible trials.

TypeScript

Apache-2.0

View repository →

io.github.cyanheads/clipboard-mcp-server

Active

Read, write, and inspect the system clipboard on macOS, Linux (X11/Wayland), and Windows via MCP.

TypeScript

Apache-2.0

View repository →

io.github.cyanheads/coingecko-mcp-server

Active

Crypto market data via CoinGecko — prices, markets, history, trending, and deep coin metadata.

TypeScript

Apache-2.0

View repository →

io.github.cyanheads/college-scorecard-mcp-server

Active

Search, compare, and analyze U.S. college data — costs, earnings, programs, and outcomes.

TypeScript

View repository →

io.github.cyanheads/congressgov-mcp-server

Active

Access U.S. congressional data - bills, votes, members, committees - via MCP.

TypeScript

Apache-2.0

View repository →