AI Skills

Differential gene expression analysis for bulk RNA-seq with PyDESeq2, including formulaic designs, Wald tests, FDR correction, LFC shrinkage, and result visualization.

中文 commit 与 changelog 配置参考——Conventional Commits 中文适配、commitlint/husky/commitizen 中文模板、conventional-changelog 中文配置。仅在用户显式 /chinese-commit-conventions 时调用，不要根据上下文自动触发。

How to use the Adaptyv Bio Foundry API and Python SDK for protein experiment design, submission, and results retrieval. Use this skill whenever the user mentions Adaptyv, Foundry API, protein binding assays, protein screening experiments, BLI/SPR assays, thermostability assays, or wants to submit protein sequences for experimental characterization. Also trigger when code imports `adaptyv`, `adaptyv_sdk`, or `FoundryClient`, or references `foundry-api-public.adaptyvbio.com`.

Train or fine-tune sentence-transformers models across `SentenceTransformer` (bi-encoder; dense or static embedding model; for retrieval, similarity, clustering, classification, paraphrase mining, dedup, multimodal), `CrossEncoder` (reranker; pair scoring for two-stage retrieval / pair classification), and `SparseEncoder` (SPLADE, sparse embedding model; for learned-sparse retrieval). Covers loss selection, hard-negative mining, evaluators, distillation, LoRA, Matryoshka, and Hugging Face Hub publishing. Use for any sentence-transformers training task.

Reference for Zustand 5.x state management including slices, middleware, Immer, useShallow, persistence, selectors, and devtools integration. Documents 7 core patterns with TypeScript examples and anti-patterns. Use when building React state management with Zustand instead of Redux.

Guide developers through capturing diagnostic artifacts to diagnose production .NET performance issues. Use when the user needs help choosing diagnostic tools, collecting performance data, or understanding tool trade-offs across different environments (Windows/Linux, .NET Framework/modern .NET, container/non-container).

Toolkit-specific Remotion patterns — custom transitions, shared components, and project conventions. For core Remotion framework knowledge (hooks, animations, rendering, etc.), see the `remotion-official` skill.

Guidelines for Python dependency management using uv, the fast Python package installer and resolver.

Create, parse, and control Excel files on macOS. Professional formatting with openpyxl, complex xlsm parsing with stdlib zipfile+xml for investment bank financial models, and Excel window control via AppleScript. Use when creating formatted Excel reports, parsing financial models that openpyxl cannot handle, or automating Excel on macOS.

Use when you need to address review or issue comments on an open GitHub Pull Request using the gh CLI.

Explore and browse available ShipSwift recipes. Use when the user says explore, browse, show recipes, list components, what's available, or wants to discover what ShipSwift offers.

Deploy CCA (Continuous Clearing Auction) smart contracts using the Factory pattern. Use when user says "deploy auction", "deploy cca", "factory deployment", or wants to deploy a configured auction.

Render a Claude-style prompt typing animation video by calling Remotion CLI against the remote site https://www.laosunwendao.com. Use when the user asks for "做一个 claude 的提示词打字机动画", "做 Claude 打字动画", "创建提示词动画", or similar requests that convert a text prompt into a typing-animation video.

Download YouTube videos and HLS streams (m3u8) from platforms like Mux, Vimeo, etc. using yt-dlp and ffmpeg. Use this skill when users request downloading videos, extracting audio, handling protected streams with authentication headers, or troubleshooting download issues like nsig extraction failures, 403 errors, or cookie extraction problems.

Create/edit .xlsx spreadsheets with formulas, charts, and data validation. Use when asked to generate Excel reports, models, or exports.

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Molecular ML with diverse featurizers and pre-built datasets. Use for property prediction (ADMET, toxicity) with traditional ML or GNNs when you want extensive featurization options and MoleculeNet benchmarks. Best for quick experiments with pre-trained models, diverse molecular representations. For graph-first PyTorch workflows use torchdrug; for benchmark datasets use pytdc.

Benchling Python SDK and REST API integration for registry entities, inventory, ELN entries, workflows, Benchling Apps, and Data Warehouse queries. Use when automating lab data with benchling-sdk or the v2 API.

Automated AI content pipeline from research to video generation using Claude, OpenAI, and Remotion

Browser automation powers web testing, scraping, and AI agent interactions. The difference between a flaky script and a reliable system comes down to understanding selectors, waiting strategies, and anti-detection patterns. This skill covers Playwright (recommended) and Puppeteer, with patterns for testing, scraping, and agentic browser control. Key insight: Playwright won the framework war. Unless you need Puppeteer's stealth ecosystem or are Chrome-only, Playwright is the better choice in 202

Create distinctive, production-grade frontend interfaces with high design quality. Use this skill when the user asks to build web components, pages, artifacts, posters, or applications (examples include websites, landing pages, dashboards, React components, HTML/CSS layouts, or when styling/beautifying any web UI). Generates creative, polished code and UI design that avoids generic AI aesthetics.

Complete toolkit for programmatic video creation with Remotion + React. Covers animations, timing, rendering (CLI/Node.js/Lambda/Cloud Run), captions, 3D, charts, text effects, transitions, and media handling. Use when writing Remotion code, building video generation pipelines, or creating data-driven video templates.

Creates a fully functional Drizzle ORM setup with a provisioned Neon database. Installs dependencies, provisions database credentials, configures connections, generates schemas, and runs migrations. Results in working code that can immediately connect to and query the database. Use when creating new projects with Drizzle, adding ORM to existing applications, or modifying database schemas.

Manages Arize users, organizations, spaces, projects, roles, role bindings, resource restrictions, and API keys via the ax CLI. Use for enterprise admin workflows: inviting and offboarding users, onboarding new teams, creating custom roles for SAML/SSO mappings, assigning roles to users, restricting project-level access, and managing service keys for multi-tenant architectures. Covers ax users, ax organizations, ax spaces, ax projects, ax roles, ax role-bindings, and ax api-keys.

Pythonic wrapper around RDKit with simplified interface and sensible defaults. Preferred for standard drug discovery including SMILES parsing, standardization, descriptors, fingerprints, clustering, 3D conformers, parallel processing. Returns native rdkit.Chem.Mol objects. For advanced control or custom parameters, use rdkit directly.

Framework for computational fluid dynamics simulations using Python. Use when running fluid dynamics simulations including Navier-Stokes equations (2D/3D), shallow water equations, stratified flows, or when analyzing turbulence, vortex dynamics, or geophysical flows. Provides pseudospectral methods with FFT, HPC support, and comprehensive output analysis.

Comprehensive deep learning guidelines for neural network development, training, and optimization.

Deep generative models for single-cell omics. Use when you need probabilistic batch correction (scVI), transfer learning, differential expression with uncertainty, or multi-modal integration (TOTALVI, MultiVI). Best for advanced modeling, batch effects, multimodal data. For standard analysis pipelines use scanpy.

Run and analyze molecular dynamics simulations with OpenMM and MDAnalysis. Set up protein/small molecule systems, define force fields, run energy minimization and production MD, analyze trajectories (RMSD, RMSF, contact maps, free energy surfaces). For structural biology, drug binding, and biophysics.

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